The first direct commercial flight between the U.S. and Cuba in more than 50 years has taken off from Fort Lauderdale, Florida, marking another historic thaw in relations between the two former Cold War enemies.

SEE ALSO:The streets of Old Havana, long before the colorful cars

The 9:45am JetBlue flight 387 will land in Santa Clara, Cuba, about 175 miles east of Havana, at a site renowned for the huge memorial that hosts the remains of revolutionary Ernesto "Che" Guevara.

JetBlue is one of six carriers -- the others being American Airlines, Delta, Frontier, Southwest and Silver Airways -- that will run a maximum of 110 daily flights to nine Cuban cities, according to the U.S. department of transportation.

“We do think it’s an important part of history,” Marty St. George, the executive vice president of JetBlue, told The New York Times. “From a challenge perspective, we know the drill. Cuba has some unique elements because of 50 years of history between the U.S. and Cuba, but we’re ready to go.”

After President Barack Obama decided to restore diplomatic relationships with Cuba in 2014, restrictions on travel to the communist-run island have eased.

Mashable Top StoriesStay connected with the hottest stories of the day and the latest entertainment news.Sign up for Mashable's Top Stories newsletterBy signing up you agree to our Terms of Use and Privacy Policy.Thanks for signing up!

Though tourism in Cuba is still illegal for U.S. citizens, there are now 12 categories of "authorized travel", including for educational, religious and humanitarian reasons.

Secretary of State John Kerry hailed the historic flight as "another step forward":

Tweet may have been deleted

JetBlue celebrated the route with salsa dancing and ribbon cutting:

Tweet may have been deleted

#HolaCuba! Our first flight to Santa Clara - the first commercial flight between the US and Cuba in more than 50 years - departs today!

A photo posted by JetBlue (@jetblue) on Aug 31, 2016 at 6:15am PDT

Tweet may have been deleted

And people tweeted pictures of the plane:

Tweet may have been deleted

Finally, the aircraft's doors closed, ready for take off:

Tweet may have been deleted